DS Scene It? Twilight (Cartridge Only)
DS Scrabble (Cartridge Only)
DS ScribbleNauts (Cartridge Only)
DS Scribblenauts CIB
DS Scripps Spelling Bee CIB
DS Sega Casino (Cartridge Only)
DS Sega Casino CIB
DS Sesame Street: Cookie’s Counting Carnival: The Video Game (Cartridge Only)
DS Shawn Johnson Gymnastics CIB
DS Sherlock Holmes: The Mystery of the Mummy CIB
DS Silly Bandz CIB
DS Sim City DS CIB
DS SimAnimals CIB
DS Six Flags Fun Park (Cartridge Only)
DS Slingo Quest (Cartridge Only)
DS Smart Boy’s Gameroom (Cartridge Only)
DS Smart Boy’s Gameroom CIB
DS Sonic Classic Collection CIB
DS Sonic Rush CIB
DS Space Champs CIB
DS Spectrobes (Cartridge Only)
DS Spectrobes: Beyond the Portals (Cartridge Only)
DS Speed Racer: The Video Game (Cartridge Only)
DS Spider-Man: Friend or Foe CIB